منابع مشابه
Dendritic epidermal T cells regulate skin antimicrobial barrier function.
The epidermis, the outer layer of the skin, forms a physical and antimicrobial shield to protect the body from environmental threats. Skin injury severely compromises the epidermal barrier and requires immediate repair. Dendritic epidermal T cells (DETC) reside in the murine epidermis where they sense skin injury and serve as regulators and orchestrators of immune responses. Here, we determined...
متن کاملmTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
Mammalian target of rapamycin (mTOR), a regulator of growth in many tissues, mediates its activity through two multiprotein complexes, mTORC1 or mTORC2. The role of mTOR signalling in skin morphogenesis and epidermal development is unknown. Here we identify mTOR as an essential regulator in skin morphogenesis by epidermis-specific deletion of Mtor in mice (mTOREKO). mTOREKO mutants are viable, ...
متن کاملEpidermal barrier formation and recovery in skin disorders.
Skin is at the interface between the complex physiology of the body and the external, often hostile, environment, and the semipermeable epidermal barrier prevents both the escape of moisture and the entry of infectious or toxic substances. Newborns with rare congenital barrier defects underscore the skin's essential role in a terrestrial environment and demonstrate the compensatory responses ev...
متن کاملAbnormal Epidermal Barrier Recovery in Uninvolved Skin supports the Notion of an Epidermal Pathogenesis of Psoriasis
Psoriasis. Due to primary genetic defects, the epidermal permeability barrier is vulnerable in psoriatic subjects. Mechanical traumas, such as scratches or abrasion, damage the skin barrier, especially during low humidity seasons, such as the winter. While barrier function can be readily maintained in normal subjects, in psoriatic patients, a compromised barrier cannot be completely repaired po...
متن کاملHistamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
BACKGROUND Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis. METHODS Human primary keratinocytes were cultured under differentiation-promoting conditions in the presence and absence of hi...
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ژورنال
عنوان ژورنال: Asian Journal of Beauty and Cosmetology
سال: 2016
ISSN: 2466-2046,2466-2054
DOI: 10.20402/ajbc.2016.0039